(19)

(11)

EP 0 842 281 A1

(12)

(43) Date of publication: 20.05.1998 Bulletin 1998/21 (21) Application number: 96924666.0 (22) Date of filing: 19.07.1996

(51) International Patent Classification (IPC):  C12N 9/ 72( . ) A61K 38/ 00( . ) C12N 15/ 58( . ) (86) International application number: PCT/US1996/012044 (87) International publication number: WO 1997/005257 (13.02.1997 Gazette 1997/08)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 31.07.1995 US 19950509208 (71) Applicant: CHIRON CORPORATION Emeryville, California 94608 (US)	(72) Inventors: ROSENBERG, Steven Oakland, CA 94602 (US) SPEAR, Kerry, L. Oakland, CA 94611 (US) VALERIO, Robert Cranbourme, VIC 3977 (AU) BRAY, Andrew Boronia, VIC 3155 (AU) (74) Representative: Irvine, Jonquil Claire, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)