(19)
(11) EP 0 842 291 A1

(12)

(43) Date of publication:
20.05.1998 Bulletin 1998/21

(21) Application number: 96925425.0

(22) Date of filing: 22.07.1996
(51) International Patent Classification (IPC): 
C12N 15/ 00( . )
A61K 31/ 35( . )
A61P 35/ 00( . )
C12N 1/ 14( . )
C12N 15/ 01( . )
C12R 1/ 645( . )
 A61K 31/ 00( . )
A61K 31/ 352( . )
C07D 493/ 04( . )
C12N 9/ 99( . )
C12P 17/ 18( . )
(86) International application number:
PCT/US1996/012114
(87) International publication number:
WO 1997/005270 (13.02.1997 Gazette 1997/08)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

(30) Priority: 25.07.1995 US 19950001414
28.03.1996 GB 19960006502

(71) Applicant: MERCK & CO., INC.
Rahway, New Jersey 07065 (US)

(72) Inventors:
  • CASCALES, Carmen
    E-28027 Madrid (ES)
  • LINGHAM, Russell, B.
    Rahway, NJ 07065 (US)
  • PELAEZ, Fernando
    E-28027 Madrid (ES)
  • POLISHOOK, Jon, D.
    Rahway, NJ 07065 (US)
  • SILVERMAN, Keith, C.
    Rahway, NJ 07065 (US)
  • SINGH, Sheo, B.
    Rahway, NJ 07065 (US)
  • ZINK, Deborah, L.
    Rahway, NJ 07065 (US)

(74) Representative: Hiscock, Ian James, et al 
European Patent Department, Merck & Co., Inc., Terlings Park, Eastwick Road
Harlow, Essex CM20 2QR
Harlow, Essex CM20 2QR (GB)

   


(54) INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE