(19)

(11)

EP 0 843 548 A2

(12)

(43) Date of publication: 27.05.1998 Bulletin 1998/22 (21) Application number: 96919250.0 (22) Date of filing: 05.06.1996

(51) International Patent Classification (IPC):  A61K 47/ 02( . ) A61K 47/ 18( . ) A61K 31/ 58( . ) (86) International application number: PCT/US1996/009651 (87) International publication number: WO 1996/040042 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.06.1995 US 19950485339 (71) Applicant: RHONE-POULENC RORER PHARMACEUTICALS, INC. Collegeville, PA 19426-0997 (US)	(72) Inventors: WON, Chong, Min Warrington, PA 18976 (US) STROHBECK, Christianna, L. Florence, SC 29501 (US) TANG, Sheng-Yuh Lansdale, PA 19446 (US) HSU, Bih-Hsiung Lansdale, PA 19446 (US) (74) Representative: Caffin, Lee  Rhône-Poulenc Rorer Limited, Rainham Road South Dagenham, Essex RM10 7XS Dagenham, Essex RM10 7XS (GB)