(19)

(11)

EP 0 843 660 A1

(12)

(43) Date of publication: 27.05.1998 Bulletin 1998/22 (21) Application number: 96924801.0 (22) Date of filing: 31.07.1996

(51) International Patent Classification (IPC):  C07D 401/ 12( . ) A61K 31/ 40( . ) A61K 31/ 404( . ) A61K 31/ 4164( . ) A61P 25/ 04( . ) A61P 25/ 28( . ) C07D 209/ 30( . ) A61K 31/ 00( . ) A61K 31/ 403( . ) A61K 31/ 415( . ) A61K 31/ 4178( . ) A61P 25/ 08( . ) C07D 209/ 18( . ) (86) International application number: PCT/DK1996/000332 (87) International publication number: WO 1997/005109 (13.02.1997 Gazette 1997/08)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 31.07.1995 DK 19950000870 (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventors: LUNDBECK, Jane, Marie DK-2900 Glostrup (DK) KANSTRUP, Anders DK-2830 Virum (DK)