(19)

(11)

EP 0 843 728 A1

(12)

(43) Date of publication: 27.05.1998 Bulletin 1998/22 (21) Application number: 96927402.0 (22) Date of filing: 12.08.1996

(51) International Patent Classification (IPC):  C07K 14/ 01( . ) C12N 15/ 82( . ) C12N 15/ 34( . ) (86) International application number: PCT/US1996/013097 (87) International publication number: WO 1997/007217 (27.02.1997 Gazette 1997/10)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 11.08.1995 US A 2158 09.04.1996 US A 15051 09.08.1996 US A 689544 (71) Applicant: UNIVERSITY OF FLORIDA Gainesville, Florida 32611-2037 (US)	(72) Inventors: HIEBERT, Ernest Gainesville, FL 32605 (US) ABOUZID, Ahmed Gainesville, FL 32607 (US) YOUNG PING DUAN Gainesville, FL 32603 (US) POWELL, Charles, A. Fort Pierce, FL 34982 (US) POLSTON, Jane, E. North Port, FL 34287 (US) (74) Representative: Perry, Robert Edward, et al  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)