(19)

(11)

EP 0 844 876 A1

(12)

(43) Date of publication: 03.06.1998 Bulletin 1998/23 (21) Application number: 96926917.0 (22) Date of filing: 06.08.1996

(51) International Patent Classification (IPC):  A61K 31/ 40( . ) A61K 31/ 409( . ) A61P 15/ 00( . ) A61K 31/ 00( . ) A61K 41/ 00( . ) (86) International application number: PCT/US1996/012828 (87) International publication number: WO 1997/006797 (27.02.1997 Gazette 1997/10)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 14.08.1995 US 19950002276 (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, California 94612-3550 (US)	(72) Inventors: TADIR, Yona Irvine, CA 92715 (US) TROMBERG, Bruce, J. Irvine, CA 92715 (US) BERNS, Michael, W. Trabuco Canyon, CA 92679 (US) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)