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(11)

EP 0 844 886 A2

(12)

(43) Date of publication: 03.06.1998 Bulletin 1998/23 (21) Application number: 96928057.0 (22) Date of filing: 14.08.1996

(51) International Patent Classification (IPC):  A61K 47/ 48( . ) C07D 259/ 00( . ) A61K 49/ 06( . ) C07F 13/ 00( . ) (86) International application number: PCT/US1996/012767 (87) International publication number: WO 1997/006824 (27.02.1997 Gazette 1997/10)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 17.08.1995 US 19950002421 (71) Applicant: MONSANTO COMPANY St. Louis, Missouri 63167 (US)

(72) Inventors: NEUMANN, William, L. Ballwin, MO 63021 (US) RILEY, Dennis, P. Ballwin, MO 63011 (US) WEISS, Randy, H. St. Louis, MO 63129 (US) HENKE, Susan, L. Webster Groves, MO 63119 (US) LENNON, Patrick, J. Clayton, MO 63105 (US) ASTON, Karl, W. Pacific, MO 63069 (US) (74) Representative: Beil, Hans Christoph, Dr., et al  Hansmann & Vogeser, Patent- und Rechtsanwälte, Postfach 80 01 40 65901 Frankfurt 65901 Frankfurt (DE)