(19)

(11)

EP 0 845 038 A1

(12)

(43) Date of publication: 03.06.1998 Bulletin 1998/23 (21) Application number: 96927785.0 (22) Date of filing: 14.08.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 1/ 20( . ) C12N 1/ 36( . ) C12P 21/ 02( . ) C07K 14/ 245( . ) C12N 1/ 21( . ) C12N 15/ 31( . ) C12R 1/ 19( . ) (86) International application number: PCT/GB1996/001988 (87) International publication number: WO 1997/007216 (27.02.1997 Gazette 1997/10)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 19.08.1995 GB 19950017026 (71) Applicant: THE VICTORIA UNIVERSITY OF MANCHESTER Manchester M13 9PL (GB)	(72) Inventor: BARBER, Jill Manchester M20 6HG (GB) (74) Representative: Atkinson, Peter Birch, et al  MARKS & CLERK, Sussex House, 83-85 Mosley Street Manchester M2 3LG Manchester M2 3LG (GB)