(19)

(11)

EP 0 845 987 A1

(12)

(43) Date of publication: 10.06.1998 Bulletin 1998/24 (21) Application number: 96930499.0 (22) Date of filing: 08.08.1996

(51) International Patent Classification (IPC):  A61K 31/ 00( . ) A61K 38/ 00( . ) A61P 1/ 16( . ) A61P 11/ 00( . ) A61P 13/ 12( . ) A61P 43/ 00( . ) C07C 311/ 19( . ) C07C 323/ 60( . ) C07F 9/ 24( . ) C07K 5/ 02( . ) A61K 31/ 40( . ) A61P 1/ 00( . ) A61P 5/ 24( . ) A61P 13/ 00( . ) A61P 17/ 00( . ) C07C 259/ 06( . ) C07C 311/ 29( . ) C07D 207/ 48( . ) C07F 9/ 40( . ) C07K 5/ 072( . ) (86) International application number: PCT/US1996/012876 (87) International publication number: WO 1997/005865 (20.02.1997 Gazette 1997/09)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 08.08.1995 US 19950602038 14.02.1996 US 19960601203 01.03.1996 US 19960609187 (71) Applicant: FIBROGEN, INC. Sunnyvale, CA 94086 (US)	(72) Inventors: BRENNER, Mitch Mountain View, CA 94040 (US) HO, Wen-Bin Los Altos, CA 94022 (US) (74) Representative: Schüssler, Andrea, Dr.  Kanzlei Huber & Schüssler Truderinger Strasse 246 81825 München 81825 München (DE)