(19)
(11) EP 0 846 116 A1

(12)

(43) Date of publication:
10.06.1998 Bulletin 1998/24

(21) Application number: 96915200.0

(22) Date of filing: 21.05.1996
(51) International Patent Classification (IPC): 
A61K 31/ 495( . )
A61P 1/ 00( . )
A61P 9/ 00( . )
A61P 13/ 12( . )
A61P 25/ 00( . )
A61P 27/ 14( . )
A61P 35/ 00( . )
A61P 43/ 00( . )
C07D 403/ 06( . )
 A61K 31/ 496( . )
A61P 7/ 00( . )
A61P 11/ 00( . )
A61P 17/ 00( . )
A61P 27/ 02( . )
A61P 29/ 00( . )
A61P 37/ 08( . )
C07D 401/ 14( . )
C07D 417/ 14( . )
(86) International application number:
PCT/JP1996/001335
(87) International publication number:
WO 1996/037489 (28.11.1996 Gazette 1996/52)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

(30) Priority: 25.05.1995 US 19950450176

(71) Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.
Osaka-shi Osaka 541 (JP)

(72) Inventors:
  • MATSUO, Masaaki
    Toyonaka-shi, Osaka 560 (JP)
  • HAGIWARA, Daijiro
    Moriguchi-shi, Osaka 570 (JP)
  • MANABE, Takashi
    Kawanishi-shi, Hyogo 666-01 (JP)
  • KONISHI, Nobukiyo
    Nagaokakyo-shi, Kyoto 617 (JP)
  • SHIGENAGA, Shinji
    Kobe-shi, Hyogo 654-01 (JP)
  • MURANO, Kenji
    Osaka-shi, Osaka 547 (JP)
  • MATSUDA, Hiroshi
    Osaka-shi, Osaka 533 (JP)
  • MIYAKE, Hiroshi
    Kyoto-shi, Kyoto 606 (JP)

(74) Representative: Türk, Gille, Hrabal, Leifert 
Brucknerstrasse 20
40593 Düsseldorf
40593 Düsseldorf (DE)

   


(54) 1-BENZOYL-2-(INDOLYL-3-ALKYL)-PIPERAZINE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS