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(11)

EP 0 846 120 A1

(12)

(43) Date of publication: 10.06.1998 Bulletin 1998/24 (21) Application number: 96914817.0 (22) Date of filing: 22.05.1996

(51) International Patent Classification (IPC):  A61K 31/ 425( . ) A61P 7/ 02( . ) A61K 31/ 505( . ) C07D 513/ 04( . ) (86) International application number: PCT/CA1996/000318 (87) International publication number: WO 1996/037497 (28.11.1996 Gazette 1996/52)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV SI (30) Priority: 22.05.1995 GB 19950010264 (71) Applicant: BIOCHEM PHARMA INC. Laval, Quebec H7V 4A7 (CA)

(72) Inventors: DIMAIO, John Montreal, Quebec H1E 4L9 (CA) GILLARD, John, W. Baie D'Urfe, Quebec H9X 2S1 (CA) SIDDIQUI, M., Arshad St-Laurent, Quebec H4R 2C4 (CA) BACHAND, Benoit Montreal, Quebec H1Z 1E9 (CA) DOHERTY, Annette, Marian Ann Arbor, MI 48103 (US) EDMUNDS, Jeremy, John Ypsilanti, MI 48197 (US) (74) Representative: Jones, Helen Marjorie Meredith, et al  Gill Jennings & Every, Broadgate House, 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)