(19)

(11)

EP 0 848 820 A1

(12)

(43) Date of publication: 24.06.1998 Bulletin 1998/26 (21) Application number: 96917970.0 (22) Date of filing: 04.06.1996

(51) International Patent Classification (IPC):  C07K 14/ 15( . ) G01N 33/ 53( . ) C07K 16/ 08( . ) G01N 33/ 569( . ) (86) International application number: PCT/US1996/008537 (87) International publication number: WO 1996/039630 (12.12.1996 Gazette 1997/02)

(84) Designated Contracting States: AT BE CH DE ES FR GB IT LI NL (30) Priority: 05.06.1995 US 19950462097 (71) Applicant: Abbott Laboratories Abbott Park, Illinois 60064-3500 (US)	(72) Inventors: NOWLAN, Sean, F. Winthrop Harbor, IL 60096 (US) HICKMAN, Keith, R. Mundelein, IL 60060 (US) SHIH, Jessie, W. Lake Forest, IL 60045 (US) CERNEY, Michael, B. Libertyville, IL 60048 (US) DEVARE, Sushil, G. Northbrook, IL 60062 (US) (74) Representative: Modiano, Guido, Dr.-Ing., et al  Modiano, Josif, Pisanty & Staub, Baaderstrasse 3 80469 München 80469 München (DE)