(19)

(11)

EP 0 850 057 A1

(12)

(43) Date of publication: 01.07.1998 Bulletin 1998/27 (21) Application number: 96929780.0 (22) Date of filing: 30.08.1996

(51) International Patent Classification (IPC):  A61K 31/ 00( . ) A61P 31/ 00( . ) A61P 35/ 00( . ) C07D 273/ 08( . ) C12N 1/ 20( . ) C12P 21/ 04( . ) A61K 31/ 395( . ) A61P 31/ 10( . ) C07D 273/ 00( . ) C07K 5/ 06( . ) C12P 21/ 02( . ) (86) International application number: PCT/US1996/013855 (87) International publication number: WO 1997/007798 (06.03.1997 Gazette 1997/11)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI NL PT SE (30) Priority: 30.08.1995 US 19950002935 (71) Applicants: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US) UNIVERSITY OF HAWAII Honolulu, HI 96822 (US) WAYNE STATE UNIVERSITY Detroit, MI 48202 (US)	(72) Inventors: MOORE, Richard, E. Honolulu, HI 96816 (US) PATEL, Vinod, F. Carmel, IN 46032 (US) RAY, James, E. Indianapolis, IN 46268 (US) TOTH, John, E. Indianapolis, IN 46278 (US) (74) Representative: Hudson, Christopher Mark, et al  Eli Lilly and Company Limited, Lilly Research Centre, Erl Wood Manor Windlesham Surrey GU20 6PH Windlesham Surrey GU20 6PH (GB)