(19)

(11)

EP 0 850 061 A1

(12)

(43) Date of publication: 01.07.1998 Bulletin 1998/27 (21) Application number: 96918849.0 (22) Date of filing: 19.06.1996

(51) International Patent Classification (IPC):  A61K 31/ 47( . ) A61K 31/ 517( . ) A61K 31/ 4709( . ) (86) International application number: PCT/JP1996/001693 (87) International publication number: WO 1997/009984 (20.03.1997 Gazette 1997/13)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 13.09.1995 JP 19950235704 (71) Applicant: Takeda Chemical Industries, Ltd. Osaka-shi, Osaka 541 (JP)	(72) Inventors: MAKINO, Haruhiko Hyogo 666-02 (JP) SOHDA, Takashi Osaka 569 (JP) OHTA, Yoshikazu Osaka 569-11 (JP) (74) Representative: von Kreisler, Alek, Dipl.-Chem., et al  Patentanwälte, von Kreisler-Selting-Werner, Bahnhofsvorplatz 1 (Deichmannhaus) 50667 Köln 50667 Köln (DE)