(19)

(11)

EP 0 850 067 A1

(12)

(43) Date of publication: 01.07.1998 Bulletin 1998/27 (21) Application number: 96924519.0 (22) Date of filing: 17.07.1996

(51) International Patent Classification (IPC):  A61K 38/ 22( . ) A61K 31/ 135( . ) A61K 31/ 19( . ) A61K 31/ 505( . ) A61K 31/ 529( . ) A61K 31/ 7028( . ) A61K 31/ 704( . ) A61P 5/ 30( . ) A61P 35/ 02( . ) A61K 31/ 00( . ) A61K 31/ 138( . ) A61K 31/ 192( . ) A61K 31/ 517( . ) A61K 31/ 70( . ) A61K 31/ 7034( . ) A61K 45/ 06( . ) A61P 35/ 00( . ) (86) International application number: PCT/US1996/011736 (87) International publication number: WO 1997/003682 (06.02.1997 Gazette 1997/07)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 17.07.1995 US 19950601465 (71) Applicant: CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) F-06560 Valbonne (FR)	(72) Inventor: FONTANA, Joseph, A. Ellicott City, MD 21043 (US) (74) Representative: Goldin, Douglas Michael, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)