(19)

(11)

EP 0 850 318 A1

(12)

(43) Date of publication: 01.07.1998 Bulletin 1998/27 (21) Application number: 96929776.0 (22) Date of filing: 21.08.1996

(51) International Patent Classification (IPC):  C12N 15/ 74( . ) C12Q 1/ 68( . ) C12N 15/ 79( . ) (86) International application number: PCT/US1996/013845 (87) International publication number: WO 1997/010360 (20.03.1997 Gazette 1997/13)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 13.09.1995 US 19950003708 16.08.1996 US 19960689926 (71) Applicant: CHIRON CORPORATION Emeryville, California 94608 (US)	(72) Inventors: GIESE, Klaus Castro Valley, CA 94552 (US) ESCOBEDO, Jaime Alamo, CA 94507 (US) (74) Representative: Goldin, Douglas Michael, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)