(19)

(11)

EP 0 851 754 A1

(12)

(43) Date of publication: 08.07.1998 Bulletin 1998/28 (21) Application number: 96932487.0 (22) Date of filing: 10.09.1996

(51) International Patent Classification (IPC):  C07D 487/ 22( . ) A61K 31/ 409( . ) A61K 41/ 00( . ) A61K 47/ 36( . ) A61K 9/ 51( . ) A61K 31/ 555( . ) A61K 47/ 32( . ) (86) International application number: PCT/EP1996/003956 (87) International publication number: WO 1997/010811 (27.03.1997 Gazette 1997/14)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 21.09.1995 DE 19589010594 (71) Applicant: Novartis AG 4058 Basel (CH)	(72) Inventors: GURNY, Robert 1204 Genève (CH) ALLEMANN, Eric Olivier 1257 Croix-de-Rozon (CH) LEROUX, Jean-Christophe Outremont Québec H2V 4P1 (CA) KRISTL, Julijana 61117 Ljubljana (SI) DOELKER, Eric 1231 Conches (CH) (74) Representative: Bastian, Werner Maria, et al  Novartis AG Geistiges Eigentum Konzern Patent- und Markenabteilung CH Postfach 4002 Basel 4002 Basel (CH)