(19)

(11)

EP 0 852 583 A2

(12)

(43) Date of publication: 15.07.1998 Bulletin 1998/29 (21) Application number: 96930092.0 (22) Date of filing: 23.08.1996

(51) International Patent Classification (IPC):  C07B 61/ 00( . ) C07H 21/ 00( . ) C07C 233/ 46( . ) C07K 1/ 04( . ) (86) International application number: PCT/EP1996/003731 (87) International publication number: WO 1997/008190 (06.03.1997 Gazette 1997/11)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 30.08.1995 GB 19950017661 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford, Middlesex TW8 9EP (GB)	(72) Inventor: HUGHES, Ian, SmithKline Beecham Pharmaceuticals Harlow, Essex CM19 5AW (GB) (74) Representative: Waters, David Martin, Dr., et al  Smithkline Beecham plc Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)