(19)

(11)

EP 0 853 621 A1

(12)

(43) Date of publication: 22.07.1998 Bulletin 1998/30 (21) Application number: 96931759.0 (22) Date of filing: 20.09.1996

(51) International Patent Classification (IPC):  A61K 31/ 00( . ) A61K 31/ 4427( . ) A61K 31/ 445( . ) A61K 31/ 4523( . ) A61P 1/ 00( . ) A61P 25/ 00( . ) A61P 25/ 16( . ) C07D 401/ 06( . ) C07D 487/ 08( . ) A61K 31/ 44( . ) A61K 31/ 444( . ) A61K 31/ 4465( . ) A61K 31/ 4545( . ) A61P 1/ 04( . ) A61P 25/ 04( . ) A61P 25/ 28( . ) C07D 453/ 02( . ) (86) International application number: PCT/DK1996/000401 (87) International publication number: WO 1997/011072 (27.03.1997 Gazette 1997/14)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 22.09.1995 DK 19950001063 16.10.1995 DK 19950001166 (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventors: OLESEN, Preben, Houlberg DK-2400 Copenhagen NV (DK) HANSEN, John, Bondo DK-4450 Jyderup (DK) HANSEN, Holger, C. DK-3500 Vaerloese (DK)