(19)

(11)

EP 0 854 706 A1

(12)

(43) Date of publication: 29.07.1998 Bulletin 1998/31 (21) Application number: 96933197.0 (22) Date of filing: 27.09.1996

(51) International Patent Classification (IPC):  G01N 33/ 68( . ) A61K 47/ 34( . ) A61K 35/ 12( . ) A61K 9/ 50( . ) C12N 5/ 071( . ) (86) International application number: PCT/US1996/015649 (87) International publication number: WO 1997/011685 (03.04.1997 Gazette 1997/15)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.09.1995 US 19950004375P 28.05.1996 US 19960018524P (71) Applicant: EMORY UNIVERSITY Atlanta, GA 30322 (US)	(72) Inventors: WEBER, Collin J. Atlanta, GA 30339 (US) CHRYSSOCHOOS, John T. Atlanta, GA 30309 (US) CHAIKOF, Elliot L. Atlanta, GA 30350 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)