(19)

(11)

EP 0 854 933 A1

(12)

(43) Date of publication: 29.07.1998 Bulletin 1998/31 (21) Application number: 96928355.0 (22) Date of filing: 04.09.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 1/ 21( . ) C12N 9/ 20( . ) C12N 15/ 10( . ) C12Q 1/ 44( . ) G01N 33/ 573( . ) C11D 3/ 386( . ) C12N 9/ 00( . ) C12N 9/ 50( . ) C12Q 1/ 37( . ) C40B 40/ 02( . ) C12R 1/ 19( . ) (86) International application number: PCT/DK1996/000368 (87) International publication number: WO 1997/009446 (13.03.1997 Gazette 1997/12)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE (30) Priority: 07.09.1995 DK 19950000988 (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventors: MARKVARDSEN, Peter DK-2880 Bagsvaerd (DK) BJORNVAD, Mads, Eskelund DK-2880 Bagsvaerd (DK) MIKKELSEN, Frank DK-2880 Bagsvaerd (DK) DIDERICHSEN, Borge DK-2880 Bagsvaerd (DK) (74) Representative: Jensen, Bo Hammer, et al  Novo Nordisk A/S, Corporate Patents BoH, Novo Allé 2880 Bagsvaerd 2880 Bagsvaerd (DK)