(19)

(11)

EP 0 855 909 A1

(12)

(43) Date of publication: 05.08.1998 Bulletin 1998/32 (21) Application number: 96930833.0 (22) Date of filing: 13.09.1996

(51) International Patent Classification (IPC):  A61K 41/ 00( . ) C07D 405/ 12( . ) C07D 305/ 14( . ) (86) International application number: PCT/US1996/014613 (87) International publication number: WO 1997/009979 (20.03.1997 Gazette 1997/13)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 13.09.1995 US 19950003687P (71) Applicant: FLORIDA STATE UNIVERSITY Tallahassee, FL. 32310 (US)	(72) Inventors: HOLTON, Robert A., Dittmer Laboratory of Chemistry Tallahassee, FL 32306 (US) NADIZADEH, Hossain Tallahassee, FL 32304 (US) HOFER, Kurt, G. Tallahassee, FL 32304 (US) YANG, Li-Xi Tallahassee, FL 32304 (US) (74) Representative: W.P. THOMPSON & CO.  Celcon House 289-293 High Holborn London WC1V 7HU London WC1V 7HU (GB)