(19)

(11)

EP 0 855 997 A1

(12)

(43) Date of publication: 05.08.1998 Bulletin 1998/32 (21) Application number: 96918506.0 (22) Date of filing: 13.06.1996

(51) International Patent Classification (IPC):  A61K 49/ 04( . ) C07C 233/ 65( . ) C07C 233/ 05( . ) C07C 237/ 46( . ) (86) International application number: PCT/US1996/010433 (87) International publication number: WO 1997/000240 (03.01.1997 Gazette 1997/02)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 16.06.1995 US 19950491135 (71) Applicant: BIOPHYSICA, INC. La Jolla, CA 92037 (US)	(72) Inventors: SOVAK, Milos La Jolla, CA 92037 (US) TERRY, Ronald, C. San Diego, CA 92117 (US) DOUGLASS, James, Gordon, III San Diego, CA 92130 (US) SELIGSON, Allen Poway, CA 92064 (US) BROWN, Jason Encinitas, CA 92024 (US) (74) Representative: Ziebig, Marlene, Dr. Dipl.-Chem., et al  Patentanwälte Gulde Hengelhaupt Ziebig Lützowplatz 11-13 10785 Berlin 10785 Berlin (DE)