(19)

(11)

EP 0 857 020 A1

(12)

(43) Date of publication: 12.08.1998 Bulletin 1998/33 (21) Application number: 96937761.0 (22) Date of filing: 23.10.1996

(51) International Patent Classification (IPC):  C07D 471/ 10( . ) A61K 9/ 36( . ) A61K 31/ 445( . ) A61K 31/ 4523( . ) A61K 47/ 38( . ) A61K 9/ 20( . ) A61K 31/ 438( . ) A61K 31/ 4465( . ) A61K 31/ 454( . ) (86) International application number: PCT/US1996/017196 (87) International publication number: WO 1997/015191 (01.05.1997 Gazette 1997/19)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 27.10.1995 US 19950005897P 27.10.1995 US 19950005901P 16.02.1996 GB 19960003238 23.02.1996 GB 19960003834 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: ASGHARNEJAD, Mandana Rahway, NJ 07065 (US) DRAPER, Jerome, P. Rahway, NJ 07065 (US) DUBOST, David, C. Rahway, NJ 07065 (US) KAUFMAN, Michael, J. Rahway, NJ 07065 (US) STOREY, David, E. Rahway, NJ 07065 (US) (74) Representative: Hiscock, Ian James  European Patent Department, Merck & Co., Inc., Terlings Park, Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)