(19)

(11)

EP 0 857 069 A1

(12)

(43) Date of publication: 12.08.1998 Bulletin 1998/33 (21) Application number: 96935088.0 (22) Date of filing: 25.10.1996

(51) International Patent Classification (IPC):  A61K 9/ 00( . ) A61K 9/ 19( . ) A61K 39/ 12( . ) A61K 47/ 12( . ) A61P 31/ 00( . ) C12N 7/ 00( . ) A61K 47/ 24( . ) A61K 9/ 107( . ) A61K 31/ 00( . ) A61K 39/ 13( . ) A61K 47/ 44( . ) A61P 31/ 12( . ) A61K 39/ 00( . ) (86) International application number: PCT/GB1996/002615 (87) International publication number: WO 1997/015331 (01.05.1997 Gazette 1997/19)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: SI (30) Priority: 25.10.1995 GB 19950021806 (71) Applicant: Cortecs (UK) Limited Isleworth, Middlesex TW7 6RL (GB)	(72) Inventors: NEW, Roger, Randal, Charles Hampstead London NW3 6QB (GB) HART, Charles Anthony The University of Liverpool Liverpool L69 3BX (GB) (74) Representative: Chapman, Paul William, et al  Kilburn & Strode, 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)