(19)

(11)

EP 0 858 332 A1

(12)

(43) Date of publication: 19.08.1998 Bulletin 1998/34 (21) Application number: 96938708.0 (22) Date of filing: 28.10.1996

(51) International Patent Classification (IPC):  A61K 31/ 336( . ) A61P 37/ 06( . ) A61K 31/ 365( . ) C07D 493/ 04( . ) (86) International application number: PCT/US1996/017482 (87) International publication number: WO 1997/016182 (09.05.1997 Gazette 1997/20)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 31.10.1995 US 19950006085P 31.10.1995 US 19950006092P 23.02.1996 GB 19960003842 09.05.1996 GB 19960009665 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: BAKER, Robert, K. Rahway, NJ 07065 (US) BAO, Jianming Rahway, NJ 07065 (US) KAYSER, Frank Rahway, NJ 07065 (US) PARSONS, William, H. Rahway, NJ 07065 (US) RUPPRECHT, Kathleen, M. Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic  Merck & Co., Inc., Terlings Park, Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)