(19)

(11)

EP 0 859 600 A1

(12)

(43) Date of publication: 26.08.1998 Bulletin 1998/35 (21) Application number: 96934274.0 (22) Date of filing: 31.10.1996

(51) International Patent Classification (IPC):  A61K 9/ 16( . ) A61K 31/ 47( . ) A61K 9/ 20( . ) A61K 47/ 04( . ) (86) International application number: PCT/CA1996/000724 (87) International publication number: WO 1997/016173 (09.05.1997 Gazette 1997/20)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 02.11.1995 US 19950006161P 29.02.1996 GB 19960004277 (71) Applicant: MERCK FROSST CANADA INC. Kirkland Quebec H9H 3L1 (CA)	(72) Inventor: BECHARD, Simon Kirkland, Quebec H9H 3L1 (CA) (74) Representative: Hiscock, Ian James, et al  European Patent Department, Merck & Co., Inc., Terlings Park, Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)