(19)

(11)

EP 0 859 633 A2

(12)

(43) Date of publication: 26.08.1998 Bulletin 1998/35 (21) Application number: 97938359.0 (22) Date of filing: 15.08.1997

(51) International Patent Classification (IPC):  C07K 16/ 24( . ) A61K 38/ 00( . ) C12N 15/ 113( . ) (86) International application number: PCT/US1997/014448 (87) International publication number: WO 1998/006431 (19.02.1998 Gazette 1998/07)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 16.08.1996 US 19960698926 04.12.1996 US 19960760299 (71) Applicant: Osther, Kurt B. Scottsdale, AZ 85254 (US)	(72) Inventor: Osther, Kurt B. Scottsdale, AZ 85254 (US) (74) Representative: Holdcroft, James Gerald, Dr., et al  Graham Watt & Co., Riverhead Sevenoaks, Kent TN13 2BN Sevenoaks, Kent TN13 2BN (GB)