(19)

(11)

EP 0 859 692 A1

(12)

(43) Date of publication: 26.08.1998 Bulletin 1998/35 (21) Application number: 96940490.0 (22) Date of filing: 07.11.1996

(51) International Patent Classification (IPC):  C07D 233/ 82( . ) (86) International application number: PCT/US1996/018403 (87) International publication number: WO 1997/017180 (15.05.1997 Gazette 1997/21)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.11.1995 US 19950554476 16.05.1996 US 19960645798 (71) Applicant: LONZA INC. Fair Lawn New Jersey 07410 (US)	(72) Inventors: FARINA, Thomas, Edward Flemington, NJ 08822 (US) GEICK, Kenneth, Scott Mercerville, NJ 08619 (US) FALTER, Julia, Anne Glen Gardner, NJ 08826 (US) (74) Representative: Browne, Robin Forsythe, Dr.  Urquhart-Dykes & Lord Tower House Merrion Way Leeds LS2 8PA West Yorkshire Leeds LS2 8PA West Yorkshire (GB)