(19)
(11) EP 0 859 760 A1

(12)

(43) Date of publication:
26.08.1998 Bulletin 1998/35

(21) Application number: 96931071.0

(22) Date of filing: 09.09.1996
(51) International Patent Classification (IPC): 
A61K 31/ 403( . )
A61P 25/ 00( . )
C07D 209/ 70( . )
A61P 9/ 00( . )
A61P 43/ 00( . )
(86) International application number:
PCT/EP1996/003990
(87) International publication number:
WO 1997/010210 (20.03.1997 Gazette 1997/13)
(84) Designated Contracting States:
BE CH DE ES FR GB IT LI NL

(30) Priority: 12.09.1995 GB 19950018572

(71) Applicant: SMITHKLINE BEECHAM PLC
Brentford, Middlesex TW8 9EP (GB)

(72) Inventors:
  • HARLING, John, David
    Harlow, Essex CM19 5AW (GB)
  • ORLEK, Barry, Sidney
    Harlow, Essex CM19 5AW (GB)

(74) Representative: Waters, David Martin, Dr. 
Smithkline Beecham plc Corporate Intellectual Property, Two New Horizons Court
Brentford, Middlesex TW8 9EP
Brentford, Middlesex TW8 9EP (GB)

   


(54) TRICYCLIC PYRROLIDINE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS