(19)

(11)

EP 0 859 790 A1

(12)

(43) Date of publication: 26.08.1998 Bulletin 1998/35 (21) Application number: 96932987.0 (22) Date of filing: 13.09.1996

(51) International Patent Classification (IPC):  C07K 14/ 74( . ) (86) International application number: PCT/US1996/014547 (87) International publication number: WO 1997/010267 (20.03.1997 Gazette 1997/13)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 14.09.1995 US 19950603744 07.03.1996 US 19960612973 (71) Applicant: PROMEGA CORPORATION Madison, WI 53711-5399 (US)	(72) Inventors: KENT, Marijo, G. Madison, WI 53711-5399 (US) AGULNIK, Alexander, I.-Baylor College of Medicine 6550 Fannin Street,Houston, TX 77030 (US) (74) Representative: Ford, Michael Frederick, et al  MEWBURN ELLIS York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)