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(11)

EP 0 859 843 A1

(12)

(43) Date of publication: 26.08.1998 Bulletin 1998/35 (21) Application number: 96936191.0 (22) Date of filing: 04.10.1996

(51) International Patent Classification (IPC):  C07K 14/ 535( . ) A61K 38/ 00( . ) C12N 15/ 19( . ) (86) International application number: PCT/US1996/015935 (87) International publication number: WO 1997/012977 (10.04.1997 Gazette 1997/16)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 05.10.1995 US 19950004832P (71) Applicant: G.D. SEARLE & CO. Chicago IL 60680-5110 (US)

(72) Inventors: ZURFLUH, Linda, L. Kirkwood, MO 63122 (US) KLEIN, Barbara, K. St. Louis, MO 63131 (US) McWHERTER, Charles, A. Wildwood, MO 63011 (US) FENG, Yiqing St. Louis, MO 63130 (US) McKEARN, John, P. St. Louis, MO 63038 (US) BRAFORD-GOLDBERG, Sarah, Ruth St. Louis, MO 63108 (US) (74) Representative: Weisert, Annekäte, Dipl.-Ing. Dr.-Ing., et al  Patentanwälte Kraus Weisert & Partner Thomas-Wimmer-Ring 15 80539 München 80539 München (DE)