(19)

(11)

EP 0 859 845 A1

(12)

(43) Date of publication: 26.08.1998 Bulletin 1998/35 (21) Application number: 96935009.0 (22) Date of filing: 15.10.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 35/ 76( . ) A61K 38/ 00( . ) A61K 48/ 00( . ) C07K 14/ 31( . ) C12N 1/ 21( . ) C12N 15/ 31( . ) C12Q 1/ 68( . ) C12R 1/ 445( . ) A61K 35/ 74( . ) A61K 36/ 06( . ) A61K 39/ 395( . ) A61P 31/ 04( . ) C07K 16/ 12( . ) C12N 15/ 00( . ) C12P 21/ 02( . ) A61K 39/ 00( . ) (86) International application number: PCT/GB1996/002532 (87) International publication number: WO 1997/014801 (24.04.1997 Gazette 1997/18)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 16.10.1995 GB 19950021148 04.03.1996 GB 19960004594 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford, Middlesex TW8 9EP (GB)	(72) Inventors: HODGSON, John Edward, SmithKline Beecham Pharm. Collegeville, PA 19426-0989 (US) BURNHAM, Martin,K.R. SmithKline Beecham Pharm. Collegeville, PA 19426-0989 (US) (74) Representative: Mallalieu, Catherine Louise, et al  D. Young & Co., 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)