(19)

(11)

EP 0 859 846 A1

(12)

(43) Date of publication: 26.08.1998 Bulletin 1998/35 (21) Application number: 96931711.0 (22) Date of filing: 04.10.1996

(51) International Patent Classification (IPC):  C07K 14/ 145( . ) A61K 39/ 00( . ) C12N 15/ 47( . ) (86) International application number: PCT/CA1996/000665 (87) International publication number: WO 1997/012981 (10.04.1997 Gazette 1997/16)

(84) Designated Contracting States: AT BE DE DK ES FR GB IT NL SE (30) Priority: 05.10.1995 US 19950539414 (71) Applicant: Microbix Biosystems Inc. Toronto, Ontario M8Z 3A8 (CA)	(72) Inventors: YAROSH, Oksana, K. Nepean, Ontario, K2H 7H1 (CA) PREVEC, Ludvik Burlington, Ontario L7T 1M9 (CA) GRAHAM, Frank, L. Hamilton, Ontario L8P 2V4 (CA) (74) Representative: Sexton, Jane Helen, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)