(19)

(11)

EP 0 859 949 A1

(12)

(43) Date of publication: 26.08.1998 Bulletin 1998/35 (21) Application number: 96939594.0 (22) Date of filing: 08.11.1996

(51) International Patent Classification (IPC):  G01N 1/ 10( . ) C07D 307/ 91( . ) G01N 1/ 34( . ) B01D 11/ 04( . ) C07D 319/ 24( . ) (86) International application number: PCT/US1996/017922 (87) International publication number: WO 1997/017601 (15.05.1997 Gazette 1997/21)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 08.11.1995 US 19950555565 07.06.1996 US 19960019243P (71) Applicant: Triangle Laboratories Inc. Durham, NC 27713 (US)	(72) Inventors: TONDEUR, Yves, G. Chapel Hill, NC 27516 (US) ALBRO, Phillip, W. Cary, NC 27511 (US) CHU, Michael, D. Durham, NC 27707 (US) (74) Representative: Boff, James Charles, et al  c/o Phillips & Leigh 7 Staple Inn Holborn London WC1V 7QF London WC1V 7QF (GB)