(19)

(11)

EP 0 861 074 A1

(12)

(43) Date of publication: 02.09.1998 Bulletin 1998/36 (21) Application number: 96925904.0 (22) Date of filing: 01.08.1996

(51) International Patent Classification (IPC):  A61K 45/ 00( . ) A61K 31/ 00( . ) A61K 31/ 22( . ) A61K 45/ 06( . ) A61P 1/ 04( . ) A61P 3/ 00( . ) A61P 7/ 00( . ) A61P 9/ 10( . ) A61P 17/ 06( . ) A61P 19/ 10( . ) A61P 31/ 00( . ) A61P 37/ 00( . ) A61P 43/ 00( . ) A61K 9/ 127( . ) A61K 31/ 08( . ) A61K 31/ 23( . ) A61P 1/ 00( . ) A61P 1/ 16( . ) A61P 3/ 10( . ) A61P 9/ 00( . ) A61P 17/ 00( . ) A61P 19/ 00( . ) A61P 29/ 00( . ) A61P 31/ 04( . ) A61P 37/ 08( . ) (86) International application number: PCT/GB1996/001861 (87) International publication number: WO 1997/004768 (13.02.1997 Gazette 1997/08)

(84) Designated Contracting States: BE DE ES FR GB IT NL SE (30) Priority: 02.08.1995 GB 19950015868 (71) Applicant: PROTEUS MOLECULAR DESIGN LIMITED Macclesfield, Cheshire SK11 0JL (GB)	(72) Inventors: ROBERTS, Craig, William Glasgow G11 (GB) BREWER, James, MacDonald Glasgow G12 9TJ (GB) ALEXANDER, James Glasgow G61 1DH (GB) (74) Representative: Grant, Anne Rosemary  Frank B. Dehn & Co. 179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)