HEXAHYDRO-5-IMINO-1,4-HETEROAZEPINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASES - Patent 0861238

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(11)

EP 0 861 238 A1

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(43)	Date of publication:
	02.09.1998 Bulletin 1998/36

(21)	Application number: 96937836.0

(22)	Date of filing: 28.10.1996

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International Patent Classification (IPC):

A61K 31/ 55^{( . )}
A61P 1/ 00^{( . )}
A61P 3/ 10^{( . )}
A61P 9/ 02^{( . )}
A61P 9/ 10^{( . )}
A61P 11/ 06^{( . )}
A61P 13/ 12^{( . )}
A61P 17/ 04^{( . )}
A61P 25/ 00^{( . )}
A61P 25/ 28^{( . )}
A61P 27/ 06^{( . )}
A61P 35/ 00^{( . )}
A61P 37/ 02^{( . )}
A61P 43/ 00^{( . )}
C07D 243/ 08^{( . )}
C07D 267/ 10^{( . )}
C07D 281/ 04^{( . )}
C07D 281/ 10^{( . )}
C07D 403/ 00^{( . )}
C07D 409/ 00^{( . )}
C07D 417/ 00^{( . )}
C07D 495/ 04^{( . )}
C07D 513/ 04^{( . )}

A61K 31/ 554^{( . )}
A61P 1/ 14^{( . )}
A61P 9/ 00^{( . )}
A61P 9/ 04^{( . )}
A61P 11/ 00^{( . )}
A61P 13/ 02^{( . )}
A61P 15/ 00^{( . )}
A61P 17/ 06^{( . )}
A61P 25/ 16^{( . )}
A61P 27/ 02^{( . )}
A61P 29/ 00^{( . )}
A61P 37/ 00^{( . )}
A61P 37/ 06^{( . )}
C07D 243/ 06^{( . )}
C07D 267/ 08^{( . )}
C07D 267/ 16^{( . )}
C07D 281/ 06^{( . )}
C07D 401/ 00^{( . )}
C07D 405/ 00^{( . )}
C07D 413/ 00^{( . )}
C07D 487/ 04^{( . )}
C07D 498/ 04^{( . )}

(86)	International application number:
	PCT/US1996/017447

(87)	International publication number:
	WO 1997/016430 (09.05.1997 Gazette 1997/20)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

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Priority:

01.11.1995 US 19950007172P
21.12.1995 US 19950009012P
12.03.1996 GB 19960005162
19.03.1996 GB 19960005700

(71)	Applicant: MERCK & CO., INC.
	Rahway, New Jersey 07065 (US)

(72)	Inventors:
	CALDWELL, Charles, G. Rahway, NJ 07065 (US) HAGMANN, William, K. Rahway, NJ 07065 (US) MacCOSS, Malcolm Rahway, NJ 07065 (US) SHAH, Shrenik, K. Rahway, NJ 07065 (US) SHANKARAN, Kothandaraman Rahway, NJ 07065 (US) FURMAN, Karla, L. Rahway, NJ 07065 (US)

(74)	Representative: Horgan, James Michael Frederic, et al
	Merck & Co., Inc., Terlings Park, Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)

(54)	HEXAHYDRO-5-IMINO-1,4-HETEROAZEPINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASES