RECOMBINANT PROTEINS HAVING MULTIPLE DISULFIDE BONDS AND THIOL-SUBSTITUTED CONJUGATES THEREOF - Patent 0861440

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EP 0 861 440 A1

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(43)	Date of publication:
	02.09.1998 Bulletin 1998/36

(21)	Application number: 96933032.0

(22)	Date of filing: 20.09.1996

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International Patent Classification (IPC):

G01N 33/ 534^{( . )}
A61K 51/ 00^{( . )}
C07K 16/ 00^{( . )}
C12N 15/ 09^{( . )}
G01N 33/ 532^{( . )}
A61K 38/ 00^{( . )}

A61K 39/ 395^{( . )}
A61K 51/ 10^{( . )}
C07K 16/ 30^{( . )}
C12P 21/ 08^{( . )}
G01N 33/ 536^{( . )}

(86)	International application number:
	PCT/US1996/014832

(87)	International publication number:
	WO 1997/011370 (27.03.1997 Gazette 1997/14)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

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Priority:

22.09.1995 US 19950004169P

(71)	Applicant: Immunomedics, Inc.
	Morris Plains, New Jersey 07950 (US)

(72)	Inventors:
	LEUNG, Shui-on Madison, NJ 07940 (US) GRIFFITHS, Gary, L. Morristown, NJ 07960 (US)

(74)	Representative: Maschio, Antonio, et al
	D Young & Co, 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)

(54)	RECOMBINANT PROTEINS HAVING MULTIPLE DISULFIDE BONDS AND THIOL-SUBSTITUTED CONJUGATES THEREOF