(19)

(11)

EP 0 862 437 A1

(12)

(43) Date of publication: 09.09.1998 Bulletin 1998/37 (21) Application number: 96938215.0 (22) Date of filing: 11.11.1996

(51) International Patent Classification (IPC):  A61K 9/ 22( . ) A61K 9/ 28( . ) A61K 31/ 517( . ) A61K 47/ 38( . ) A61K 9/ 20( . ) A61K 31/ 505( . ) A61K 47/ 30( . ) (86) International application number: PCT/EP1996/005020 (87) International publication number: WO 1997/018814 (29.05.1997 Gazette 1997/23)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: LV RO SI (30) Priority: 21.11.1995 GB 19950023752 (71) Applicants: Pfizer Research and Development Company, N.V./S.A. Dublin 1 (IE) Pfizer Limited Sandwich Kent CT13 9NJ (GB)	(72) Inventors: MACRAE, Ross, James Sandwich Kent CT13 9NJ (GB) SMITH, Janet, Sarah Sandwich Kent CT13 9NJ (GB) (74) Representative: Hayles, James Richard  Pfizer Limited, Patents Department, Ramsgate Road Sandwich Kent CT13 9NJ Sandwich Kent CT13 9NJ (GB)