METHODS OF REDUCING APOLIPOPROTEIN E4-INDUCED INHIBITION OF NEURON REMODELING - Patent 0862460

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EP 0 862 460 A1

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(43)	Date of publication:
	09.09.1998 Bulletin 1998/37

(21)	Application number: 96909506.0

(22)	Date of filing: 20.02.1996

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International Patent Classification (IPC):

A61K 45/ 00^{( . )}
A61K 38/ 16^{( . )}
A61K 38/ 40^{( . )}
A61P 25/ 00^{( . )}
A61P 43/ 00^{( . )}

A61K 38/ 00^{( . )}
A61K 38/ 17^{( . )}
A61K 39/ 395^{( . )}
A61P 25/ 28^{( . )}
C07K 16/ 18^{( . )}

(86)	International application number:
	PCT/US1996/002447

(87)	International publication number:
	WO 1997/014437 (24.04.1997 Gazette 1997/18)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

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Priority:

17.10.1995 US 19950005550P
19.01.1996 US 19960659785

(71)	Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
	Oakland, California 94612-3550 (US)

(72)	Inventors:
	MAHLEY, Robert, W. Lafayette, CA 94549 (US) WEISGRABER, Karl, H. Walnut Creek, CA 94595 (US) PITAS, Robert, E. Orinda, CA 94563 (US)

(74)	Representative: Goldin, Douglas Michael
	J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)

(54)	METHODS OF REDUCING APOLIPOPROTEIN E4-INDUCED INHIBITION OF NEURON REMODELING