(19)

(11)

EP 0 862 497 A1

(12)

(43) Date of publication: 09.09.1998 Bulletin 1998/37 (21) Application number: 96936933.0 (22) Date of filing: 24.10.1996

(51) International Patent Classification (IPC):  G01N 1/ 00( . ) B01L 3/ 00( . ) G01N 35/ 02( . ) G01N 35/ 00( . ) B01J 19/ 00( . ) B01L 3/ 02( . ) C40B 60/ 14( . ) (86) International application number: PCT/US1996/017072 (87) International publication number: WO 1997/015394 (01.05.1997 Gazette 1997/19)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 24.10.1995 GB 19950021775 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US)	(72) Inventors: BAINS, William, Arthur Hertfordshire SG8 6BW (GB) HOUZEGO, Peter, John Cambridge, CB4 5AD (GB) (74) Representative: Blakey, Alison Jane  Intellectual Property Department, Jealotts Hill Research Station, P.O. Box 3538 Bracknell, Berkshire RG42 6YA Bracknell, Berkshire RG42 6YA (GB)