(19)

(11)

EP 0 863 758 A1

(12)

(43) Date of publication: 16.09.1998 Bulletin 1998/38 (21) Application number: 96928463.0 (22) Date of filing: 14.08.1996

(51) International Patent Classification (IPC):  A61K 31/ 485( . ) (86) International application number: PCT/EP1996/003592 (87) International publication number: WO 1997/006801 (27.02.1997 Gazette 1997/10)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 18.08.1995 ZA 19950006923 16.11.1995 FR 19950013613 (71) Applicant: Parke Davis 92400 Courbevoie (FR)	(72) Inventors: NOUALHAC, Henri F-45160 Olivet (FR) COURTEILLE, Frédéric F-45400 Fleury-les-Aubrais (FR) LARGIER, Timothy, Walter Retreat 7945 (ZA) (74) Representative: Pochart, François  Cabinet Hirsch-Desrousseaux-Pochart, 34 rue de Bassano 75008 Paris 75008 Paris (FR)