NOVEL MACROCYCLIC COMPOUNDS AS METALLOPROTEASE INHIBITORS - Patent 0863885

(19)

(11)

EP 0 863 885 A2

(12)

(43)	Date of publication:
	16.09.1998 Bulletin 1998/38

(21)	Application number: 96943497.0

(22)	Date of filing: 13.11.1996

(51)

International Patent Classification (IPC):

C12Q 1/ 37^{( . )}
A61K 31/ 395^{( . )}
A61K 31/ 407^{( . )}
A61K 31/ 416^{( . )}
A61K 31/ 4178^{( . )}
A61K 31/ 42^{( . )}
A61K 31/ 425^{( . )}
A61K 31/ 44^{( . )}
A61K 31/ 445^{( . )}
A61K 31/ 4523^{( . )}
A61K 31/ 496^{( . )}
A61K 31/ 5375^{( . )}
A61K 38/ 00^{( . )}
A61P 29/ 00^{( . )}
C07D 255/ 02^{( . )}
C07D 273/ 02^{( . )}
C07D 291/ 08^{( . )}
C07D 403/ 04^{( . )}
C07D 413/ 12^{( . )}
C07D 419/ 12^{( . )}
C07D 521/ 00^{( . )}
C07K 5/ 06^{( . )}
C07K 5/ 065^{( . )}
C07K 5/ 078^{( . )}

A61K 31/ 00^{( . )}
A61K 31/ 40^{( . )}
A61K 31/ 415^{( . )}
A61K 31/ 4164^{( . )}
A61K 31/ 4184^{( . )}
A61K 31/ 422^{( . )}
A61K 31/ 427^{( . )}
A61K 31/ 4427^{( . )}
A61K 31/ 4465^{( . )}
A61K 31/ 495^{( . )}
A61K 31/ 535^{( . )}
A61K 31/ 5377^{( . )}
A61K 49/ 00^{( . )}
C07D 245/ 02^{( . )}
C07D 267/ 00^{( . )}
C07D 291/ 02^{( . )}
C07D 401/ 12^{( . )}
C07D 403/ 12^{( . )}
C07D 417/ 12^{( . )}
C07D 498/ 08^{( . )}
C07K 5/ 02^{( . )}
C07K 5/ 062^{( . )}
C07K 5/ 068^{( . )}

(86)	International application number:
	PCT/US1996/018382

(87)	International publication number:
	WO 1997/018207 (22.05.1997 Gazette 1997/22)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

(30)

Priority:

14.11.1995 US 19950006684P
08.05.1996 US 19960646902
01.11.1996 US 19960743439

(71)	Applicant: THE DU PONT MERCK PHARMACEUTICAL COMPANY
	Wilmington, Delaware 19898 (US)

(72)

Inventors:

XUE, Chu-Biao
Hockessin, DE 19707-2400 (US)
CHERNEY, Robert, Joseph
Newark, DE 19711-2449 (US)
DeCICCO, Carl, Peter
Newark, DE 19711-8300 (US)
DeGRADO, William, Frank
Media, PA 19063-4207 (US)
HE, Xiaohua
Hockessin, DE 19707-1406 (US)
HODGE, Carl, Nicolas
Wilmington, DE 19808-2967 (US)
JACOBSON, Irina, Cipora
Wilmington, DE 19810-3427 (US)
MAGOLDA, Ronald, Louis
Wallingford, PA 19086-6209 (US)
ARNER, Elizabeth, Catherine
West Grove, PA 19390-9412 (US)
DUAN, Jingwu
Newark, DE 19711-2497 (US)
NELSON, David, J.
Newark, DE 19702-1444 (US)

(74)	Representative: Pett, Christopher Phineas, et al
	Frank B. Dehn & Co., European Patent Attorneys, 179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)

(54)	NOVEL MACROCYCLIC COMPOUNDS AS METALLOPROTEASE INHIBITORS