(19)

(11)

EP 0 863 893 A1

(12)

(43) Date of publication: 16.09.1998 Bulletin 1998/38 (21) Application number: 96936810.0 (22) Date of filing: 22.10.1996

(51) International Patent Classification (IPC):  A61K 31/ 00( . ) A61K 31/ 445( . ) A61K 31/ 4523( . ) A61P 7/ 00( . ) C07D 401/ 12( . ) A61K 31/ 4427( . ) A61K 31/ 4465( . ) A61K 31/ 454( . ) A61P 7/ 02( . ) (86) International application number: PCT/US1996/016882 (87) International publication number: WO 1997/015568 (01.05.1997 Gazette 1997/19)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 26.10.1995 US 19950005890P 16.02.1996 GB 19960003245 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: HUTCHINSON, John, H. Rahway, NJ 07065 (US) HALCZENKO, Wasyl Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic  Merck & Co., Inc., Terlings Park, Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)