(19)

(11)

EP 0 866 705 A1

(12)

(43) Date of publication: 30.09.1998 Bulletin 1998/40 (21) Application number: 96936505.0 (22) Date of filing: 15.10.1996

(51) International Patent Classification (IPC):  A61K 31/ 00( . ) A61K 31/ 415( . ) A61K 31/ 4427( . ) A61K 31/ 445( . ) A61K 31/ 4523( . ) A61P 7/ 00( . ) C07D 401/ 06( . ) C07D 405/ 14( . ) C07D 521/ 00( . ) A61K 31/ 38( . ) A61K 31/ 44( . ) A61K 31/ 4439( . ) A61K 31/ 4465( . ) A61K 31/ 4545( . ) A61P 7/ 02( . ) C07D 401/ 14( . ) C07D 453/ 04( . ) C07K 5/ 06( . ) (86) International application number: PCT/US1996/016491 (87) International publication number: WO 1997/014417 (24.04.1997 Gazette 1997/18)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 19.10.1995 US 19950005602P 16.02.1996 GB 19960003371 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)

(72) Inventors: ASKEW, Ben, C. Rahway, NJ 07065 (US) HARTMAN, George, D. Rahway, NJ 07065 (US) DUGGAN, Mark, E. Rahway, NJ 07065 (US) YOUNG, Steven, D. Rahway, NJ 07065 (US) HUTCHINSON, John, H. Rahway, NJ 07065 (US) WAI, John, S. Rahway, NJ 07065 (US) EGBERTSON, Melissa, S. Rahway, NJ 07065 (US) VASSALLO, Laura, M. Rahway, NJ 07065 (US) LIBBY, Laura, A. Rahway, NJ 07065 (US) IHLE, Nathan, C. Rahway, NJ 07065 (US) KRAUSE, Amy, E. Rahway, NJ 07065 (US) HALCZENKO, Wasyl Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic  Merck & Co., Inc., Terlings Park, Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)