(19)

(11)

EP 0 866 708 A1

(12)

(43) Date of publication: 30.09.1998 Bulletin 1998/40 (21) Application number: 96941406.0 (22) Date of filing: 15.11.1996

(51) International Patent Classification (IPC):  A61K 31/ 00( . ) A61K 31/ 506( . ) A61K 31/ 529( . ) A61P 3/ 06( . ) A61P 9/ 06( . ) A61P 15/ 00( . ) A61P 27/ 00( . ) C07D 239/ 22( . ) C07D 491/ 04( . ) A61K 31/ 505( . ) A61K 31/ 519( . ) A61P 3/ 00( . ) A61P 9/ 00( . ) A61P 9/ 12( . ) A61P 15/ 10( . ) A61P 27/ 02( . ) C07D 401/ 12( . ) C07D 491/ 048( . ) (86) International application number: PCT/US1996/018573 (87) International publication number: WO 1997/017969 (22.05.1997 Gazette 1997/22)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 16.11.1995 WO 1995US15025 16.05.1996 US 19960648770 (71) Applicants: SYNAPTIC PHARMACEUTICAL CORPORATION Paramus, New Jersey 07652-1410 (US) MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: NAGARATHNAM, Dhanapalan Ramsey, NJ 07446 (US) WONG, Wai, C. Newark, NJ 07102 (US) MIAO, Shou, Wu Edison, NJ 08820 (US) PATANE, Michael, A. Harleysville, PA 19438 (US) GLUCHOWSKI, Charles Wayne, NJ 07470 (US) (74) Representative: Lawrence, John, et al  Barker Brettell 138 Hagley Road Edgbaston Birmingham B16 9PW Birmingham B16 9PW (GB)