(19)

(11)

EP 0 866 807 A1

(12)

(43) Date of publication: 30.09.1998 Bulletin 1998/40 (21) Application number: 96936035.0 (22) Date of filing: 27.09.1996

(51) International Patent Classification (IPC):  C07K 14/ 705( . ) A61K 38/ 00( . ) C07K 16/ 28( . ) (86) International application number: PCT/US1996/015575 (87) International publication number: WO 1997/011971 (03.04.1997 Gazette 1997/15)

(84) Designated Contracting States: DE ES FR GB IT (30) Priority: 28.09.1995 US 19950004489P 26.09.1996 US 19960721612 (71) Applicant: ALEXION PHARMACEUTICALS, INC. New Haven, CT 06511 (US)

(72) Inventors: MUELLER, John, P. Old Lyme, CT 06371 (US) EVANS, Mark, J. Radnor, PA 19087 (US) MUELLER, Eileen, Elliott Old Lyme, CT 06371 (US) ROLLINS, Scott Oxford, CT 06478 (US) ROTHER, Russell, P. Cheshire, CT 06410 (US) MATIS, Louis, A. Southport, CT 06490 (US) (74) Representative: Froud, Clive, et al  Elkington and Fife Prospect House 8 Pembroke Road Sevenoaks, Kent TN13 1XR Sevenoaks, Kent TN13 1XR (GB)