(19)

(11)

EP 0 866 867 A2

(12)

(43) Date of publication: 30.09.1998 Bulletin 1998/40 (21) Application number: 96917875.0 (22) Date of filing: 31.05.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 1/ 21( . ) C12N 9/ 12( . ) A61K 38/ 00( . ) C12N 1/ 19( . ) C12N 5/ 10( . ) C12N 15/ 54( . ) C12R 1/ 19( . ) (86) International application number: PCT/US1996/008097 (87) International publication number: WO 1996/040937 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 07.06.1995 US 19950480019 (71) Applicant: Abbott Laboratories Abbott Park, Illinois 60064-3500 (US)	(72) Inventors: COWART, Marlon, D. Round Lake Beach, IL 60073 (US) HALBERT, Donald, N. Libertyville, IL 60048 (US) KERWIN, James, F., Jr. Grayslake, IL 60030 (US) MCNALLY, Teresa Gurnee, IL 60031 (US) (74) Representative: Modiano, Guido, Dr.-Ing., et al  Modiano, Josif, Pisanty & Staub, Baaderstrasse 3 80469 München 80469 München (DE)