(19)

(11)

EP 0 866 871 A1

(12)

(43) Date of publication: 30.09.1998 Bulletin 1998/40 (21) Application number: 96942887.0 (22) Date of filing: 05.12.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 38/ 00( . ) A61K 38/ 20( . ) A61K 39/ 39( . ) A61P 37/ 00( . ) C07K 14/ 315( . ) C07K 14/ 54( . ) C07K 14/ 74( . ) C07K 17/ 06( . ) A61K 31/ 00( . ) A61K 38/ 19( . ) A61K 39/ 00( . ) A61K 39/ 395( . ) A61P 37/ 04( . ) C07K 14/ 535( . ) C07K 14/ 55( . ) C07K 16/ 24( . ) C07K 19/ 00( . ) (86) International application number: PCT/US1996/019327 (87) International publication number: WO 1997/020940 (12.06.1997 Gazette 1997/25)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.12.1995 US 19950568343 (71) Applicant: HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE Rockville, MD 20852 (US)	(72) Inventors: MOND, James, J. Potomac, MD 20854 (US) SNAPPER, Clifford, M. Potomac, MD 20854 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät  Maximilianstrasse 58 80538 München 80538 München (DE)