(19)

(11)

EP 0 868 187 A1

(12)

(43) Date of publication: 07.10.1998 Bulletin 1998/41 (21) Application number: 96944042.0 (22) Date of filing: 20.12.1996

(51) International Patent Classification (IPC):  A61K 31/ 565( . ) A61K 31/ 00( . ) A61P 15/ 00( . ) A61K 9/ 70( . ) A61K 31/ 57( . ) A61P 15/ 12( . ) (86) International application number: PCT/EP1996/005759 (87) International publication number: WO 1997/023227 (03.07.1997 Gazette 1997/29)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE (30) Priority: 22.12.1995 DE 19951048332 (71) Applicant: Rotta Research B.V. 1017 PS Amsterdam (NL)	(72) Inventors: CORDES, Günter D-40764 Langenfeld (DE) SANTORO, Antonino I-20052 Monza (IT) SETNIKAR, Ivo I-20052 Monza (IT) (74) Representative: Forstmeyer, Dietmar, Dr. rer. nat., Dipl.-Chem., et al  Boeters & Bauer, Bereiteranger 15 81541 München 81541 München (DE)